This is especially interesting in light of a recent report that REST has a protective effect on Alzheimer's disease (AD) and mild cognitive impairment in aging brains (75), as well as several studies documenting that REST plays a role in neurodegenerative and neurodevelopmental diseases including Huntington's disease (HD), Down syndrome and schizophrenia (SZ) (76–82). This evidence concerns the gene REST and early-onset autosomal dominant Alzheimer disease.