Using transparent dorsal skin fold window chamber, we found that tumors in T7-OCT4 conjugate treated mice showed decreased visible microvessels on Day 12 after tumor injection (as showed in Additional file 3: Figure S2), as compared to other treatment groups, which had abundant microvessels in the tumor mass as early as Day 7 after tumor-injection. This evidence concerns the gene POU5F1 and neoplasm.