POU5F1 and neoplasm: Consistently, our results also showed that although OCT4 protein alone can promote the generation of IFN-γ which are secreted by CD8+ T cells and CD4+ T cells(especially TH1 cells)in vitro and in vivo, however, immunization of OCT4 antigen alone in vivo could not efficiently inhibit the growth EC tumors, suggesting that although systemic immune response could be activated by OCT4 protein, no tumor-specific immune responses was observed in vivo during this process.