The Hepatitis B × antigen (HBx), which is involved in HBV-related hepatocellular carcinoma (HCC), was shown to be able to down-regulate the expression miR-373 which correspondingly reduces E-cadherin expression, suggesting that HCC with low miR-373 expression level might be more invasive [29]. This evidence concerns the gene CDH1 and hepatocellular carcinoma.