Finally, the relationship between clinico-pathological variables (sex, age at diagnosis, family history of CRC, tumour stage or microsatellite instability (MSI), KRAS-mutant status and BRAF-mutant status) and genotype at rs72647484, rs10904849 and rs16941835 was assessed by case-only logistic regression (Supplementary Table 7). The gene discussed is BRAF; the disease is neoplasm.