Notably, the results showed that CXCL13 mRNA expression was obviously correlated with tumor grade, lymph node status or ER status; CXCL13 mRNA expression was significantly up-regulated in grade 2/3 (P = 0.046/ P = 0.035), lymph node positive (P = 0.012) or ER negative group (P = 0.005) (Fig. 5a). The gene discussed is ESR1; the disease is neoplasm.