However, a randomized controlled study in 300 patients with type 2 diabetes and elevated NT-proBNP (>125 pg/ml) demonstrated that accelerated up-titration of renin-angiotensin-aldosterone system- and beta-blockers to maximum tolerated dosages was an effective and safe intervention for the primary prevention of CVD events. This evidence concerns the gene NPPB and type 2 diabetes mellitus.