NOTCH1 and adrenal cortex carcinoma: Furthermore, Notch-1 knockdown was also associated with a significantly higher proportion of necrotic cells (17.2 ± 1.8 %) compared to non-infected ACC-M cells (3.7 ± 0.5 %) or ACC-M cells infected with lentiviral vectors bearing scrambled siRNA (2.4 ± 0.7 %) (p < 0.01) (Fig. 6c).