For instance, Larkin and colleagues [20] described 2 tumors that harbored alterations in both CTNNB1 and BRAF. Furthermore, ACP tumors with CTNNB1 mutation contain cells that do not demonstrate intranuclear β-catenin accumulation [21] and it has been suggested that some of the cells that comprise the tumor may not actually be CTNNB1 mutant “tumor” cells at all [22]. This evidence concerns the gene CTNNB1 and neoplasm.