MMP12 and chronic obstructive pulmonary disease: ACP was also found to overexpress MMP9 (FC = 41.0, p = 9.8 × 10−14) and, more strikingly, MMP12 (FC = 819.7, p = 3.0 × 10−49) (Fig. 1c), which are both inhibited by AZD1236, a drug originally tested as a treatment for chronic obstructive pulmonary disease, but more recently investigated as an antitumor agent.