However, tau is not only abnormally phosphorylated but also aggregates into insoluble forms such as PHFs and NFTs (Andorfer et al. 2003; Citron 2010) in various AD mouse models (Götz et al. 2001; Denk and RichardWade-Martins 2009; Baglietto-Vargas et al. 2014). This evidence concerns the gene MAPT and Alzheimer disease.