Subgroup analysis of the overall cohort showed that the risk estimate for the primary end point associated with linagliptin versus total comparators was not increased by the following factors: age, gender, race, use of rescue therapy, occurrence of hypoglycemia, Framingham 10-year CHD risk score (≤15% or >15%), renal function, microalbuminuria, or use of background medication (insulin and/or metformin) (Table 9). The gene discussed is INS; the disease is Hypoglycemia.