Compared with SQCC, on the other hand, the frequency of positive RTKs among the LCNEC and SCLC tumors was significantly higher for c-Kit (LCNEC: 49 %, SCLC: 47 %, and SQCC: 4 %) and lower for EGFR (LCNEC: 41 %, SCLC: 31 %, and SQCC: 69 %), IGF1R (LCNEC: 31 %, SCLC: 28 %, and SQCC: 62 %), and c-Met (LCNEC: 2 %, SCLC: 6 %, and SQCC: 14 %). Here, EGFR is linked to small cell lung carcinoma.