Two reports regarding integrative genomic analyses of SCLC have shown that transcriptional deregulation (for example, via RB1, SOX2, and MYC family members and chromatin modifiers) might have a role in its biology.(Peifer et al. 2012; Rudin et al. 2012) To date, however, attempts to develop targeted therapies for these transcriptional deregulations have had limited success. This evidence concerns the gene RB1 and small cell lung carcinoma.