Regarding the strongly positive RTKs, the LCNEC group exhibited strongly positive c-Kit in five tumors, EGFR in three, IGF1R in two, and KDR and ERBB2 in one each; thus, a total of 12 (24 %) LCNEC tumors had some kind of strongly positive RTK. This evidence concerns the gene KIT and large cell neuroendocrine carcinoma.