The NPM1-mutated cell line OCI-AML3 was also highly sensitive to OTX015, confirming results reported by Dawson et al [16] showing efficacy of I-BET151 in this cell line, as well as in a murine model of NPM1-mutated AML and in primary patient samples harboring NPM1 mutations. Here, NPM1 is linked to acute myeloid leukemia.