In addition, three genetic variations in GPX1 were shown to modulate PCA risk in different European populations, with genotype for rs1050450 found to modify the relationship between serum Se concentration and disease risk, with men carriers of the T allele having a reduced risk of PCA (odds ratio (OR) = 0.87 [0.76–0.99]; P = 0.04, Pinteraction = 0.03) or high-grade PCA (OR = 0.64 [0.49–0.83]; P = 0.001, Pinteraction < 0.001) per 10 μg/L increase in serum Se concentration [60] and genotype for rs17650792 and rs1800668 linked to advanced PCA risk [52]. Here, GPX1 is linked to posterior cortical atrophy.