Since MnSOD and TXNRD2 proteins play a key role in the control of the mitochondrial redox status [78] and since GPX4 knock-down in Caco-2 gut epithelial cells results in the disruption of mitochondrial function [80], this suggests that of these SNPs may impact disease risk by affecting mitochondrial function and may have different consequences depending on the environmental/lifestyle factors associated with CRC in these distinct populations. Here, GPX4 is linked to colorectal carcinoma.