GPX1 and breast carcinoma: In addition, a polymorphism in the GPX1 gene, resulting in various lengths for a polyalanine sequence in the N-terminal region of the protein (between 5 and 7 Ala) was found to alter subcellular localisation of GPx1 protein and response to oxidative damage in breast cancer cells [33], suggesting that GPx1 subcellular localisation plays a key regulatory role in GPx1 activity.