Finally, the coding SNP Thr92Ala (rs225014) in type 2 deiodinase (IDI2) gene has been linked with type 2 diabetes [106,107,108] and an association of four SNPs in the SEPP1 gene (2 coding SNPs: rs28919926; and rs146125471; one intronic SNP: rs16872779 and rs7579 in the 3′UTR) with fasting insulin and first phase insulin response was replicated in Hispanic cohorts [109]. Here, INS is linked to type 2 diabetes mellitus.