Moreover, in a US population, genetic variants in TNXRD2, Selenoprotein N, and Selenoprotein X genes were associated with survival after diagnosis with rectal cancer whereas SNPs in Selenoprotein N and Selenoprotein X were linked to colon cancer mortality and SNPS in TNXRD1-2 were shown to interact with both aspirin and cigarette smoking to alter colon and rectal cancer risk [87]. The gene discussed is SELENON; the disease is colonic neoplasm.