The role of SePP in CRC carcinogenesis was further highlighted by the observation of a reduced expression of the protein in tumour samples compared with normal mucosa and the genomic instability of a polymorphic (TC)5/(TC)3 repeats in the SEPP1 promoter in CRC cases [83,86] and the identification of a polymorphism at SEPP1 promoter region (TC)5/(TC)3 repeats and colon cancer risk [83]. This evidence concerns the gene SELENOP and neoplasm.