In a small Scottish study (~300 cases, 189 controls), CC carriers exhibited a significantly lower erythrocyte GPx1 activity (eGPX) and an increased CRC risk [77].On the contrary, in a Czech population (832 cases, 705 controls), the T allele was associated with greater CRC risk [78] and no association was observed in a Korean population (827 cases, 727 controls) [79]. This evidence concerns the gene GPX1 and colorectal carcinoma.