In a Caucasian population from New Zealand, where the soil is poor in Se and Se intake is low [100], rs7901303 and rs17529609 in selenophosphate synthetase 1 (SEPHS1) and rs1553153 in Sec tRNA synthase (SEPSECS) were significantly associated with Crohn’s Disease [13]. Here, SEPHS1 is linked to Crohn disease.