TLR4 and neoplasm: Polysaccharides can also activate some signalling receptors in the membranes of macrophages, such as Toll-like receptor-4 (TLR-4), cluster of differentiation 14 (CD14), competent receptor-3 (CR-3) and scavenging receptor (SR) [295]; these are also activated by other intracellular pathways, involving several other protein-kinases, that enhance the production of NO, which, in turn, plays an important role in causing tumour apoptosis [295].