X-ray crystallography showed isomeric 1 and 2 to have similar structures, each with a conformation akin to the letter L. The cytotoxic studies of all the compounds were carried out against MCF-7 (estrogen receptor-positive human breast cancer) and MDA-MB-231 (estrogen receptor-negative human breast cancer) cell lines and their IC50 values were determined. The gene discussed is ESR1; the disease is breast carcinoma.