STAT1 and systemic lupus erythematosus: In a large-scale DNA methylation investigation, DNA hypomethylation was found in interferon-regulated genes in lupus naïve T cells, including IFI44L, IFIT1, IFIT3, MX1, STAT1, USP18, BST2 and TRIM22, suggesting abnormalities in T cell progenitors [42].