PRKCD and systemic lupus erythematosus: More convincing evidence of ERKs role in the pathogenesis of SLE is shown in PKCδ “knock-out” mice which develop lupus-like symptoms [48,49], as well as dnMEK mouse model with autoimmune phenotype by inhibiting ERK signaling [50], indicating a critical role of this signaling pathway and the subsequent potential effect of epigenetic changes.