The group of Jean Rosenbaum (Bordeaux, France) is investigating the functions of Pontin and Reptin in hepatocellular carcinoma where these proteins are overexpressed (Rousseau et al., 2007; Haurie et al., 2009; Menard et al., 2010; Grigoletto et al., 2013). The gene discussed is RUVBL1; the disease is hepatocellular carcinoma.