Tommaso Mello (Florence, Italy), in collaboration with Oksana Bereschenko (Perugia, Italy) (Bereshchenko et al., 2012), investigated the onset and progression of hepatocellular carcinoma using a hepatocyte-conditional Pontin+/− mouse model and the Diethylnitrosamine cancer induction protocol. The gene discussed is RUVBL1; the disease is hepatocellular carcinoma.