As such, the regions identified lie in the promoters of genes already well-defined as having a role in cancer, for example RASSF1A (Hoque et al., 2006; Skvortsova et al., 2006), APC (Hoque et al., 2006; Radpour et al., 2011) and SOX17 (Chimonidou et al., 2013a). The gene discussed is APC; the disease is cancer.