Recent advances in cancer biology have demonstrated that PI3K-AKT-mTOR signaling pathway controls Fanconi anemia group D2 protein (FANCD2) and ribonucleotide reductase (RNR) and further prolongation of radiation-induced gamma H2AX foci formation (Choi et al., 2010; Shen et al., 2013; Wang et al., 2014). This evidence concerns the gene NR2E3 and cancer.