Among the prosurvival pathways activated by RTKs, PI3K-AKT-mTOR signaling pathway is frequently upregulated in human tumors and regarded as one of the most challenging prosurvival pathways involved in the resistance to cancer treatment (Engelman, 2009; Liu et al., 2010; Castellano and Downward, 2011). Here, AKT1 is linked to cancer.