NRAS and cancer: If one compares pediatric cancers to colorectal cancer which have an incidence of 400 cases per million in the USA (Haggar and Boushey, 2009), and a bias toward particular predictive biomarkers such as KRAS or NRAS mutation (Douillard et al., 2013) the feasibility of applying this technique to colorectal and other common cancers is clear.