Somatic mutations of THRB have been previously described in hepatocellular, renal cell carcinoma and other cancers but do not present a pivotal role in human thyroid carcinogenesis as we and others, were unable to detect THRB mutations in human follicular thyroid adenomas, PTC or FTC (Rocha et al., 2007; Ramos-Prol et al., 2013). This evidence concerns the gene THRB and hereditary clear cell renal cell carcinoma.