SNCA and Parkinson disease: In acetyltransferase p300 (which is a new component of cellular aggregates in α-synuclein positive Lewy bodies of patients affected by PD), a highly disordered regions was found that displays similarities with prion-like domains, is encoded as an alternative spliced variant independently of the acetyltransferase domain, and provides an interaction interface for various misfolded proteins, promoting their aggregation (Kirilyuk et al., 2012).