The illustrative examples of this phenomenon include up-regulation of alpha-1-antichymotrypsin in HCC (Ishihara et al., 2011) and non-small-cell lung carcinoma (NSCLC) (Zeng et al., 2010); down-regulation of insulin-like growth factor binding protein 3 in HCC (Chen et al., 2011) and NSCLC (Zeng et al., 2010); up-regulation of galectin-3-binding protein (Gal3BP or Mac-2 BP) in HCC (Chen et al., 2011) and ovarian cancer (Tian et al., 2011a); and increased expression of periostin in most ovarian cancer subtypes (Tian et al., 2011a) and aggressive prostate cancer (Tian et al., 2011b). This evidence concerns the gene IGFBP3 and non-small cell lung carcinoma.