AS of the IL1RL1 gene encoding interleukin-1 receptor-like 1 or ST2 protein produces two forms of the protein, a transmembrane (ST2L) form and a soluble form (sST2), the levels of which are elevated in serum of CVD patients with heart failure or MI (Willems et al., 2012). The gene discussed is IL1RL1; the disease is myocardial infarction.