The illustrative examples of this phenomenon include up-regulation of alpha-1-antichymotrypsin in HCC (Ishihara et al., 2011) and non-small-cell lung carcinoma (NSCLC) (Zeng et al., 2010); down-regulation of insulin-like growth factor binding protein 3 in HCC (Chen et al., 2011) and NSCLC (Zeng et al., 2010); up-regulation of galectin-3-binding protein (Gal3BP or Mac-2 BP) in HCC (Chen et al., 2011) and ovarian cancer (Tian et al., 2011a); and increased expression of periostin in most ovarian cancer subtypes (Tian et al., 2011a) and aggressive prostate cancer (Tian et al., 2011b). This evidence concerns the gene IGFBP3 and hepatocellular carcinoma.