Chromosomal translocation can affect transcription factors, as illustrated by the EWS-ATF or EWS-Fli1 hybrids, where the DNA-binding elements of transcription factors ATF1 or Fli1 are fused to the disordered transactivation domain of the EWS oncogene to generate an aberrant transcription factor related to Ewing sarcoma (Ng et al., 2007). The gene discussed is FLI1; the disease is Ewing sarcoma.