REST and neoplasm: Ubiquitination-deubiquitination of a master transcriptional repressor that acts as a tumor suppressor or oncogene in diverse types of cancers, the RE-1 silencing transcription factor (REST) or neuron-restrictive silencer factor (NRSF), controls levels of this protein in cancer, and abnormal upregulation of REST has been found in medulloblastoma, neuroblastoma, and glioblastoma (Huang and Bao, 2012).