The importance of this protein is determined by the fact that the ETV6 chromosomal translocations are among the most commonly observed chromosomal abnormalities in human leukemia and myelodysplastic syndrome (Baens et al., 1996), where there are 48 chromosomal bands involved in ETV6 translocations, insertions, or inversions, with at least 28 translocations being characterized at the molecular level and 30 ETV6 partner genes being identified (De Braekeleer et al., 2012). Here, ETV6 is linked to leukemia.