PRPF6 and cancer: As far as potential molecular mechanisms of the aberrant AS in cancer are concerned, recent study of human primary and metastatic colon cancer samples clearly indicated that the cancer proliferation can be driven by the overexpression or amplification of a component of the tri-small ribonucleoprotein (tri-snRNP) spliceosome complex, the pre-mRNA processing factor 6 (PRPF6), which commonly occurs in colon tumorigenesis (Adler et al., 2014; Lokody, 2014).