On the other hand, in the model, arthritis was also associated with increased expression of the cyclooxygenase (COX)-2 gene; and administration of non-steroidal anti-inflammatory drugs (NSAIDS) reversed the COX’s inhibitory effect of arthritis on BW, increased liver IGF-1 levels, and enhanced the expression of ubiquitin-ligating enzymes. This evidence concerns the gene IGF1 and arthritic joint disease.