An additional analysis of these pathways using haplotype and tagSNP screening approaches identified 68 SNPs associated with NTD risk in genes from the folate metabolic pathway, MTHFR and mitochondrial folate transporter (MFTC); DNA methylation, DNA (cytosine-5)-methyltransferase 3A (DNMT3A); B12 metabolism, Cubilin (CUBN) and choline metabolism, phosphatidylethanolamine N-methyltransferase (PEMT) (34). The gene discussed is DNMT3A; the disease is neural tube defect.