It was interesting to note that some of the previously reported biomarker oncoproteins (e.g., IL-4, CAIX, TNF-α, MCP-1, GM-CSF, VEGF, TIE2, IL17, IL-6, IFNG) did not display differential expression between Dukes’ CRC stages (P ≈ 1.0) [22-32]. The gene discussed is TNF; the disease is colorectal carcinoma.