This study has identified eight proteins (CEA, IL-8, prolactin, amphiregulin, PDGF-BB, IL-6, CXCL11 and CXCL5) whose expression trends are of great interest for developing a “biosignatures” of CRC progression that could potentially be translated into a diagnostic/prognostic. This evidence concerns the gene CXCL11 and colorectal carcinoma.