In that study, Thorsen et al., investigated 74 different protein biomarkers and found carcinoembryonic antigen (CEA), transferrin receptor-1 (TFRC), macrophage migration inhibitory factor (MIF), osteopontin (OPN/SPP1) and cancer antigen 242 (CA242) as CRC discriminators. The gene discussed is SPP1; the disease is colorectal carcinoma.