ABCB10 and cystic fibrosis: Cystic fibrosis (CF), gout, intrahepatic cholestasis types 2 and 3 (liver bile diseases), Tangier disease (HDL deficiency), Dubin-Johnson syndrome (jaundice), hyperinsulimic hypoglycemia of infancy, pseudoxanthoma elasticum, multidrug resistance, secretory diarrheas, anemia, diabetes, and atherosclerosis are examples of potentially lethal or debilitating conditions caused by genetic mutations or altered activity of one of the 48 human ABC proteins (2).