MFN1 and dilated cardiomyopathy: The silencing of MARF (mitochondrial assembly regulatory factor – ortholog of mammalian, Mitofusin) and OPA1 in the Drosophila fly heart tube causes dilated cardiomyopathy, which could be rescued by over-expressing either of the human Mitofusins (MFN1 or MFN2) or superoxide dismutase 1, implicating impaired mitochondrial fusion and oxidative stress in the pathogenesis of the heart failure (Dorn, 2011).