SENP3 and ischemia: The SUMO-2/3-specific protease SENP3 is also found to be degraded during ischaemia, via a pathway involving the unfolded protein response (UPR) kinase PERK and the lysosomal enzyme cathepsin B. Ischaemia-induced cell death is suppressed as depletion of SENP3 prolongs Drp1 SUMOylation.