A low level of EFEMP1 expression was found in the remaining osteosarcoma cases, 20 cases of normal bone tissues, 10 cases of osteoblastoma, 10 cases of osteoma, 6 cases of osteoid osteoma and 12 cases of tumor-like bone lesions (osteofibrous dysplasia and fibrous dysplasia; Figure 1A). The gene discussed is EFEMP1; the disease is osteosarcoma.