Efficient conversion of ADP to AHP and decrease of AP threshold in the caps−lpH+ neurons of diabetic rats under 50 μM of Ni2+ (Fig 4e) and selective Cav3.2 blocker, amiloride [30–32] also proves that Cav3.2 channels determine excitability of the neurons under STZ-induced diabetes. This evidence concerns the gene CACNA1H and diabetes mellitus.