Increased expression of CDKN2A has been shown to be as a result of promoter demethylation [48,49] and recently it has been shown that presence of up-regulated CDKN2A expression, promotes apoptosis and cellular senescence of bone marrow-derived mesenchymal stem cells observed in SLE patients [50]. The gene discussed is CDKN2A; the disease is systemic lupus erythematosus.