In addition, the results of Luminex immunoassay showed that significantly elevated levels of VEGF and IL-8 were detected in the supernatant of BGC-823 cells treated with 10 % GC-MSC-CM in comparison to the other groups (P < 0.05) (Fig. 5F), suggesting a more effective promoting role of GC-MSCs in tumor cell angiogenesis than GCN-MSCs or BM-MSCs. This evidence concerns the gene CXCL8 and neoplasm.