Conversely, mRNA levels of VEGF, MIP-2, TGF-β1, IL-6, and IL-8 were all significantly up-regulated in GCN-MSCs or BM-MSCs after 10 % BGC-823-CM or MKN-28-CM treatment (Fig. 5B and Fig. 6A), suggesting a converted progression of non-malignant MSCs by tumor cells. This evidence concerns the gene IL6 and neoplasm.