While the Pgam5 deficiency resulted in the induction of PD resembling disorder in knock out mice, over expression of the protein in differentiated neurons (LUHMES cells) did not change the gene expression of any of the tested 84 PD-related genes, neither in vehicle-treated control nor in 100 μM 6-OHDA-treated cells. This evidence concerns the gene PGAM5 and Parkinson disease.