The intrastriatal administration of 6-OHDA in rodents creates pathological events similar to human PD: formation of aggregated alpha synuclein bodies, proteasome inhibition, increased ubiquitination, nitration and oxidation of proteins, gluthathione depletion, and caspase 3 cleavage (Blesa et al. 2012). The gene discussed is SNCA; the disease is Parkinson disease.