PGAM5 is also responsible for dephosphorylating and activating ASK1, a higher order MAP kinase responsible for induction of neuronal apoptosis via p38- JNK axis in 6-OHDA and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of PD (Ouyang and Shen 2006; Takeda et al. 2009). The gene discussed is PGAM5; the disease is Parkinson disease.