Multivariate analysis using Cox proportional hazards model showed that TNM staging and HMGB1 (p = 0.000 and p = 0.008, respectively), but not CC3 and Ki67 (p = 0.998 and p = 0.347, respectively) were independent prognostic factors in CRC patients (Table 4). Here, HMGB1 is linked to colorectal carcinoma.