AIFM1 and auditory neuropathy: In 2006, we mapped a novel X-linked auditory neuropathy locus (AUNX1) to chrXq23-q27.3 in a large five-generation Chinese family.10 Using WES and confirmatory segregation analysis, we now report a novel missense change, p.R451Q in AIFM1, as causally responsible for the phenotype in this family.