PLS k-nearest neigbors radial basis machine identified DAPK1, MDGI, BRCA1, P15, PGK1, PGR, SYK, THBS1, 14-3-3σ, APAF1, CALCA and CCND2, as differentially methylated genes between progressing and non-progressing cancers. The gene discussed is SYK; the disease is cancer.