This group of genes contained controllers of cell proliferation (P15, CCND2, PGR) and apoptosis (APAF1, DAPK1), p53 interactors (THBS1, DAPK1), signaling kinases (SYK, PGK1, DAPK1), drivers of tumor development (BRCA1, 14-3-3 [50]), suggesting direct relevance of differentially-methylated/regulated genes for breast cancer development or progression. The gene discussed is APAF1; the disease is breast cancer.