EWSR1 and Ewing sarcoma: The oncogenic fusion proteins EWS-FLI1 and PAX3-FOXO1 are required for the growth of Ewing sarcoma and rhabdomyosarcoma cells, respectively.29, 30 Levels of the EWS-FLI1 protein in EW8 cells or the PAX3-FOXO1 protein in Rh41 cells were decreased by knockdown of Sgt1 expression.