PHLPP1 and colorectal cancer: Sgt1 mRNA levels are elevated in colorectal cancer, and this increased expression is linked to an increased rate of recurrence and poorer prognosis.22 In gastric tumor cells, overexpression of Sgt1 upregulates Akt phosphorylation through the degradation of the phosphatase PHLPP1 by enhancing the interaction of PHLPP1 with SCF-β-TrCP.23 These findings suggest that overexpression of Sgt1 is involved in tumorigenesis.