In light of our finding that levels of the EWS-FLI1 protein in EW8 cells or PAX3-FOXO1 protein in Rh41 cells were decreased by the knockdown of Sgt1 expression, it is plausible that destabilization of the onco-proteins is a mechanism of tumor suppression that results from the Sgt1 heterozygous knockout. The gene discussed is EWSR1; the disease is neoplasm.