Like Sgt1, Cdc37 is a co-chaperone of Hsp90, is overexpressed in different types of cancer cells, and is thought to be an oncogene.31 Although overexpression of Cdc37 in mice causes tumors after long latency,32 there has been no report that describes cellular transformation induced by Cdc37 overexpression. The gene discussed is CDC37; the disease is cancer.