This is of particular interest since work from other groups already demonstrated that high Cav1 expression is associated with epithelial tumor cell radioresistance at least in pancreatic and lymphoblastoid tumor cells.41, 42, 43 Thus, Cav1 might be a promising target for new combinatorial therapies to overcome therapy resistance by sensitizing both, radioresistant tumor cells and the radioresistant tumor vasculature, to the cytotoxic effects of ionizing radiation. This evidence concerns the gene CAV1 and neoplasm.