Of note, recent investigations revealed that blocking the secreted Cav1 by polyclonal antibodies inhibited the growth of experimental prostate tumors in mice.70 Nevertheless, the accelerated growth of the untreated prostate tumors in the Cav1-deficient background hints to a potential risk of treatment strategies targeting endothelial Cav1 for improving the radiation response in these tumors. This evidence concerns the gene CAV1 and prostate neoplasm.