Consistent with earlier findings we demonstrate that the increased expression of Cav1 in epithelial cancer cells of advanced human prostate cancer tissue specimen was paralleled by a reduction of Cav1 in the tumor stroma, which is well known to have a more reactive phenotype in advanced prostate carcinoma.67, 68, 69 However, here we show for the first time that alterations in stromal Cav1 levels did not include the tumor vasculature. Here, CAV1 is linked to Familial prostate cancer.