Silencing of Cav1 in pancreatic cancer cell lines resulted in the disruption of its interactions with beta1-integrin and focal adhesion kinase leading to reduced cell adhesion, proliferation and survival after exposure to ionizing radiation.40, 41, 42 Similarly, Cav1 expression also protected lymphoblastoid TK6 from radiation-induced apoptosis.43 Here, CAV1 is linked to familial pancreatic carcinoma.