As presented in this work, GM extract attenuates lupus-associated cardiac apoptosis in lupus-prone mice by down-regulating TNF-α/TNF-α receptors and Fas/FADD and reducing amounts of activated caspase-9, Bax, activated caspase-8 and activated caspase-3. The gene discussed is FADD; the disease is systemic lupus erythematosus.