In order to analyze the relationship among these three things (IGBP7, MetS case/ control status, and IR), we calculated the association of IGFBP7 with MetS modified by HOMA-IR, age, sex, the significance between IGFBP7 and MetS still remained with the OR of 3.497 (95%CI: 2.796-4.375). Here, IGFBP7 is linked to metabolic syndrome.