We selected Notch signaling to assess its role in STS metastasis because of its reported crosstalks with other oncogenic signaling pathways like EGFR, NF-κB, Akt, Sonic hedgehog (Shh), mammalian target of rapamycin (mTOR), Ras, Wnt, platelet-derived growth factor (PDGF), TGFβ and androgen receptor signaling which pave tumor aggressiveness23, 24, 25. The gene discussed is SHH; the disease is neoplasm.