Regarding different adjustment sets across studies, crude correlation coefficients were calculated in the case-control study [38], whereas the models in the cross-sectional study in Swedish elderly men were adjusted for alcohol intake, physical activity, abdominal obesity and insulin sensitivity [36], and the models in the cross-sectional study in middle-aged and older Chinese were adjusted for age, sex, region and residence [37]. The gene discussed is INS; the disease is Abdominal obesity.