Furthermore, these FISH assays can be used as an adjunctive method to improve the accuracy of diagnosis for Xp11.2 tRCC, ASPS, PEComas, and other neoplasms that are characterized by a rearrangement of the TFE3 gene and the presence of the ASPL-TFE3 fusion gene. The gene discussed is TFE3; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.