MUC16 and cancer: CA125 is a high-molecular-weight mucin-like glycoprotein that is overexpressed on the surface of ovarian cancer cells and is secreted by other cancer cells types.4,11,12 It is described as the most useful serologic marker for ovarian cancer detection and management,8,13 and plays a potential role in PDAC pathogenesis and diagnosis.3,8,14 Our previous studies demonstrated that as an independent predictor, serum CA125 levels were related to distant metastasis.