STAT3 and breast carcinoma: In addition, DE inhibits survival signaling through the Janus tyrosine kinase (JAK)-signal transducer and activator of transcription-3 (STAT3) signaling and induces apoptosis in breast cancer MDA-MB-231 cells by up-regulation of BAX and BAD, down-regulation of BCL-2 and BCL-XL, and nuclear relocation of the mitochondrial factors apoptosis-inducing factor and Endo G [23].