Hsu et al. found that DE induces apoptosis in liver cancer HepG2 and PLC/PRF/5 cells by increase of Ca2+ mobilization and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38, which subsequently causes c-Jun NH2-terminal kinase (JNK) activation and results in AIF and Endo G nuclear relocation, triggering apoptosis [6]. Here, MAPK3 is linked to liver cancer.