Here we are the first to report that GPR65 is expressed in primary human Chronic Lymphocytic Leukemia (CLL) cells and that GPR65 expression levels in these cells correlate strongly with expression levels of the anti-apoptotic Bcl-2 family members Bcl-2, Mcl-1, and Bcl-xl. Here, GPR65 is linked to B-cell chronic lymphocytic leukemia.