BCL2 and B-cell chronic lymphocytic leukemia: This observation, combined with the observed correlation between GPR65 mRNA levels and Bcl-2 mRNA levels raises interest in the potential role of microRNAs in the regulation of GPR65 expression, particularly in view of previous evidence that miR-15a and miR-16 are frequently deleted or down regulated in CLL samples with 13q14 deletions, contributing to elevated expression of Bcl-2 [30–34].