Bortezomib, first-in-class drug approved for multiple myeloma and relapsed/refractory mantle zone lymphoma (MCL), binds to the β-subunits of the core of the proteasome and inactivates NF-κB by stabilization of the NF-κB-inhibitor IκB kinase complex [31]. This evidence concerns the gene NFKB1 and plasma cell myeloma.