Although historically it has been recognized that NF-κB pathway is engaged in ABC-type DLBCL through chronic active BCR signaling, a recent work has shown that the members of the NF-κB transcription factors (NF-κB1, NF-κB2, RELA, RELB, and REL) are expressed in 88% of tissue derived from both ABC and GCB type of DLBCL [21]. This evidence concerns the gene RELB and diffuse large B-cell lymphoma.