A report by Cambien et al. in 1992 first predicted the strong relationship of the ACE D allele as an independent risk factor for myocardial infarction (MI) [3], and studies were later conducted intensively to investigate the relationship between ACE gene I/D polymorphisms and CAD in different individuals from different populations, yet their results were inconsistent [6, 7]. The gene discussed is ACE; the disease is coronary artery disorder.