PVN infusion of AT1-R blocker losartan or pyrrolidine dithiocarbamate (PDTC, a specific NF-κB inhibitor) attenuated the decreases in GABA, and the increases in gp91phox (a subunit of NAD(P)H oxidase), NF-κB activity, glutamate and NE, in the PVN of HF rats, and also attenuated the increases in RSNA and plasma PICs and NE. The gene discussed is AGTR1; the disease is hydrops fetalis.