PVN infusion of SN50 (a competitive inhibitor of the translocation of NF-κB to the nucleus) prevented the decreases in PVN GABA and GAD67, and the increases in RSNA and PVN glutamate, NE, TH, superoxide, gp91phox, phosphorylated IKKβ and NF-κB p65 activity observed in heart failure rats. This evidence concerns the gene NFKB1 and heart failure.