This is also supported by our findings that PVN infusion of a TNF-α blocker pentoxifylline (PTX) or etanercept (ETN) attenuates the increase in renal sympathetic nerve activity (RSNA), decreases AT1-R expression and modulates neurotransmitters thereby attenuating sympathoexcitation in HF rats [35]. The gene discussed is AGTR1; the disease is hydrops fetalis.