The adhesion mechanism of endothelial cell induced by HCC cells was generally considered to be related to the secretion of VEGF, FGF-2 by HCC cells, and integrins (α1β1 and α2β1), VE-cadherin, and PECAM-1 upregulated in endothelial cells, which could improve the adhesion effect of endothelial cells to HCC cells [25]. Here, CDH5 is linked to hepatocellular carcinoma.