EIF4EBP1 and neoplasm: As expected, we found a decrease in phosphorylation of the mTORC1 targets p70S6K, ribosome protein S6, and eIF4E-binding protein 1 (4E-BP1) in tumor lysates from tumors implanted with the PEM compared with those in control tumors (Figures 2(a) and 2(b)).